SINGLE-CELL RNA-SEQ REVEALED PROFOUND IMMUNE ALTERATION IN THE PERIPHERAL BLOOD OF PATIENTS WITH BACTERIAL INFECTION

Single-cell RNA-Seq revealed profound immune alteration in the peripheral blood of patients with bacterial infection

Objectives: Bacterial infection remains one of the greatest threats to human health.However, how human hosts respond to bacterial infection has not been thoroughly understood.Better understanding of this response will improve human health.Methods: Here, we conducted an investigation on host response to bacterial infection using unperturbed clinical

read more

Asymmetric Inheritance of Cell Fate Determinants: Focus on RNA

During the last decade, and mainly primed by major developments in high-throughput sequencing technologies, the catalogue of RNA molecules harbouring regulatory functions has increased at a steady pace.Current evidence indicates that hundreds of mammalian RNAs have regulatory roles at several levels, including transcription, Boot Hooks translation/

read more

Patellar articular cartilage defect treated by minced cartilage graft and fibrin glue technology: A case report

Introduction: Patellar cartilage defects are difficult entities to deal with due to the complexity of patellofemoral joints.First-line treatment of patellar chondral defects often fails despite the technical aspect of surgical procedure and there are no relevant literature STAND recommendations for failed treatment as a second line therapy.Case rep

read more